Reverse transcriptase-IN-1
CAS No. 2380001-43-2
Reverse transcriptase-IN-1 ( —— )
Catalog No. M26414 CAS No. 2380001-43-2
Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 200 | Get Quote |
|
10MG | 290 | Get Quote |
|
25MG | 492 | Get Quote |
|
50MG | 709 | Get Quote |
|
100MG | 972 | Get Quote |
|
500MG | 1962 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameReverse transcriptase-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionReverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7 nM.
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DescriptionReverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7 nM. (In Vitro):Reverse transcriptase-IN-1 has antiviral activity with EC50 values of 3.4 nM, 4.3 nM and 3.6 nM for HIV-1 IIIB, E138K and K103N mutants, respectively.(In Vivo):The PK study and safety assessment of Reverse transcriptase-IN-1 shows that it is absorbed with mean residence times (MRTs) of 11.8 hours (5 mg/kg, p.o.) and 11.4 hours (1 mg/kg, i.v.) at these two doses. The Cmax of Reverse transcriptase-IN-1 is 39.9 ng/mL at a dose of 5 mg/kg. The oral bioavailability of Reverse transcriptase-IN-1 is significantly improved to 16.5% at a dose of 5 mg/kg in rats. The intrinsic rat microsome clearance of Reverse transcriptase-IN-1 is 33.2 μL/min/mg proteins.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetHIV
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2380001-43-2
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Formula Weight447.5
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Molecular FormulaC25H17N7O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCc1cc(\C=C\C#N)cc(c1Nc1nc(Nc2ccc(cc2)C#N)nc2ccccc12)[N+]([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Atta-ur-Rahman, et, al. Antifungal aryltetralin lignans from leaves of Podophyllum hexandrum. Phytochemistry. 1995 Sep; 40(2): 427-431.
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